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Lactobacillus Rhamnosus

Mar 16, 2022

The Health  Benefits of Lactobacillus Rhamnosus GG (LGG)

Lactobacillus Rhamnosus GG (LGG) is a gut-friendly bacteria found in most digestive health supplements and fermented foods and beverages. Along with being one of the most popular strains on the market, it is also the most clinically studied bacteria. Lactobacillus Rhamnosus (LGG) is both its Latin name and scientific name. It is easier to say than spell: (LAK toe ba SIL us ram NOE sus) [1].

In 2020, a group of scientists announced name changes for some of the bacteria in the Genus Lactobacillus. Now that gene sequencing is available, they can better tell which bacteria are closely related and their new names reflect that relationship. Lactobacillus Rhamnosus LGG is updated to read as Lacticaseibacillus rhamnosus GG [2]. 

The Clear Story of Lactobacillus Rhamnosus (LGG)

In 1983, researchers Sherwood Gorbach and Barry Goldin isolated a bacterial strain in human intestines. They later named it Lactobacillus Rhamnosus GG (LGG). The 'GG' represents the first initial in both of their last names. The two men filed for a patent in April 1985, forever staking their claim on what will become one of the most marketed probiotics. In their patent, Gorbach and Goldin specified that their strain produces lactic acid and tolerates the acidic environment of the digestive tract well. Their patent stated that the cells in the intestinal walls bonded easily with the LGG bacteria, helping to speed up the healing process [3]. 

Early on, the health benefits of L. Rhamnosus were simply hearsay and not scientific fact. However, clinical studies increased dramatically as probiotics and alternative treatments grew popular over the last few decades. These studies have proven that Lactobacillus Rhamnosus LGG does help treat gastrointestinal disorders. According to VTT Biotechnology and Food Researchers in Finland, ingesting the gut-friendly bacteria has helped prevent, alleviate or cure multiple digestive conditions that include the following:

  • Lactose intolerance 
  • Viral and bacterial diarrhea, 
  • Abdominal radiotherapy side effects 
  • Constipation
  • Inflammatory bowel disease
  • Food allergies [4]

Researchers found in more recent studies that probiotics like Lactobacillus Rhamnosus offer actual health benefits and more physicians are recommending their use.

Benefits of L. Rhamnosus (LGG)

Researchers Goldin, Gorbach and Chang, a virologist, treated patients suffering relapses of the toxin known as Clostridium difficile colitis (C-diff) with L. Rhamnosus LGG. Their study showed that the C-diff patients treated with antibiotics and then Lactobacillus GG had no diarrhea relapses. These results demonstrated that this unique bacteria does have actual health benefits. In 2008, a study showed that patients infected with E. Coli took LGG and prevented intestinal damage [5].

LGG has also proven effective in combating many other troubling gut pathogens. This probiotic inhibits Clostridium, Bacteroides, Pseudomonas, Staphylococcus, Streptococcus and Enterobacteria—yet does not inhibit other beneficial Lactobacilli. ("New Research Reveals Probiotic’s Anti-Toxin, Anti-Inflammatory, Immune Boosting Properties" 2009) 

Research continues as both the medical field and patients become more aware that maintaining the digestive tract’s microbiome has whole-body benefits. New research from 2018 shows that probiotics can also improve liver function. The study focused specifically on Lactobacillus Rhamnosus GG’s ability to increase the liver's antioxidant response and prevent damaging oxidative stress [6].

Lactobacillus Rhamnosus GG continues to amaze the medical world with how resilient and versatile this species of bacteria is. The more clinical studies done, the more confirmation researchers find on how many infections and autoimmune issues LGG prevents or improves. 

Research areas such as Rheumatoid Arthritis, Irritable Bowel Syndrome (IBS) and Cystic Fibrosis (CF) are showing great promise of using LGG bacterial therapy as a possible treatment in the future. Autoimmune disorder research shows positive results with IGG treatment for  Inflammatory Bowel Disease (IBD). IBD is the catch-all name for life-altering conditions such as Crohn’s, Ulcerative Colitis (UC) and Pouchitis with LGG [7]. 

Antibiotic use often destroys the balance of good and bad bacteria in the digestive tract resulting in gastric distress and diarrhea. Lactobacillus Rhamnosus has proven successful in reducing diarrhea caused by antibiotics. It has also significantly reduced intestinal discomfort and Traveller's Diarrhea that often affects tourists. Studies also showed that taking LGG during an active rotavirus infection shortened the recovery time and minimized bouts of diarrhea. It also shortened the time the virus shed into the study participants' stool [7].

Additional uses for LGG that are still in the research phase include healing gastric ulcers, reducing allergic responses and building tolerance to the lactose present in cow's milk. Other uses still in clinical research involve L. Rhamnosus’ effect on respiratory illness, cavities and a healthy immune system that can overcome pathogens [8].

How is Lactobacillus Rhamnosus LGG Used?

The most common use for Lactobacillus Rhamnosus GG is preventing intestinal discomfort and diarrhea. It's also regularly used to restore the balance of the microbiome after a bout of acute diarrhea, antibiotic use, or cancer treatments like chemotherapy and radiation. 

Lactobacillus Rhamnosus GG (LGG) is available in the following forms:

  • Fermented foods (yogurt, kimchi, sauerkraut & cheese)
  • Fermented drinks (kombucha, kefir, cultured teas)
  • Sourdough bread
  • Cucumbers/pickles
  • Probiotic powders
  • Probiotic liquids
  • Capsules
  • Tablets
  • Digestive health & immunity supplements

Restoring balance to your intestinal flora using a probiotic supplement like Clear Gut & Immunity or Clear Lip & Skin Health supports healthy digestion, eases gastric discomfort and enhances the immune system. Keeping digestive discomfort at a minimum improves your mood and energy levels, allowing you to enjoy life without being sidelined by stomach issues.

Why Clear Probiotics Utilizes Lactobacillus Rhamnosus GG (LGG)

With some help from Clear Probiotics, focusing on your health and wellness just became easier with Clear Gut & Immunity. Probiotics like LGG help the microbiome remain balanced, a critical factor in the whole body’s health, including the immune system. Clear Probiotics chooses to use Lactobacillus Rhamnosus because hundreds of clinical studies prove it helps minimize digestive issues.  

The Science of Lactobacillus Rhamnosus LGG/ The Research Behind Lactobacillus Rhamnosus LGG 

New research sheds light on how popular probiotic benefits the gut

Lactobacillus rhamnosus GG is known to be a helpful microbe in the intestines. Researchers now understand why it's so essential to human health. Their findings show promise that the bacteria may support other gut microbes.

Promoting a Healthy Microbiome with Food and Probiotics

The Whole Heath Library provides a comprehensive list of what foods to eat to promote a healthy microbiome. You'll also find information on supplementing your diet with probiotic supplements containing LGG.

Lactobacillus rhamnosus GG improves glucose tolerance through alleviating ER stress and suppressing macrophage activation in db/db mice.

Getting metabolic syndrome under control reduces other risk factors like heart disease. LGG has shown to be a viable alternative to certain medications with serious side effects.

Resources:

  1. Segers, Marijke E, and Sarah Lebeer. “Towards a better understanding of Lactobacillus rhamnosus GG--host interactions.” Microbial cell factories vol. 13 Suppl 1, Suppl 1 (2014): S7. Accessed January 14, 2022: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4155824/ 
  2. The importance of probiotic names -- and why some of them have changed. EurekAlert! News Release April 2020. [Internet] Accessed January 14, 2022: https://www.eurekalert.org/news-releases/895939 
  3. Lactobacillus rhamnosus. Bionity's Life Science Encyclopedia. Bionity.com [Internet] Accessed January 14, 2022: https://www.bionity.com/en/encyclopedia/Lactobacillus_rhamnosus.html 
  4. Alander M, Satokari R, Korpela R, Saxelin M, Vilpponen-Salmela T, Mattila-Sandholm T, von Wright A. Persistence of colonization of human colonic mucosa by a probiotic strain, Lactobacillus rhamnosus GG, after oral consumption. Appl Environ Microbiol. 1999 Jan;65(1):351-4. doi: 10.1128/AEM.65.1.351-354.1999. PMID: 9872808; PMCID: PMC91031. Accessed January 14, 2022: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC91031/ 
  5. Clinical Education Staff. Lactobacillus GG: A Potent Immune Regulator Effective in Many Disorders. Clinical Education. [Internet] 2009. Accessed January 14, 2022: https://www.clinicaleducation.org/resources/reviews/lactobacillus-gg-a-potent-immune-regulator-effective-in-many-disorders/ 
  6. Experimental Biology 2018. "Growing evidence that probiotics are good for your liver: In mice, probiotic treatment shown to protect against liver damage from acetaminophen." ScienceDaily. [Internet] Accessed January 14, 2022: www.sciencedaily.com/releases/2018/04/180423085445.htm  
  7. Maija Saxelin, Ph.D. LGG • Summatim - Lactobacillus GG and its health effects. (2002) Clinical Education. [PDF] Accessed on January 14, 2022: https://www.clinicaleducation.org/wp-content/uploads/LGG_Summatim_english.pdf 
  8. Biljana Novkovic, Ph.D. 12+ Benefits of Lactobacillus rhamnosus (L. rhamnosus). SelfDecode. [Internet] September 2021. Accessed January 14, 2022: https://supplements.selfdecode.com/blog/l-rhamnosus/

* These statements have not been evaluated by the FDA. Clear products are not intended to diagnose, treat, cure, or prevent any disease. This website does not offer medical advice.